Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax3  paired box 3   (Synonyms: Pax-3, Splchl2)
Results	Reference
1*	J:78010 Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS, Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem. 2002 Jul 26;277(30):27294-304
1*	J:74736 Barbera JP, Rodriguez TA, Greene ND, Weninger WJ, Simeone A, Copp AJ, Beddington RS, Dunwoodie S, Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet. 2002 Feb 1;11(3):283-93
1*	J:245730 Bardot P, Vincent SD, Fournier M, Hubaud A, Joint M, Tora L, Pourquie O, The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818
1	J:216520 Beck-Cormier S, Escande M, Souilhol C, Vandormael-Pournin S, Sourice S, Pilet P, Babinet C, Cohen-Tannoudji M, Notchless is required for axial skeleton formation in mice. PLoS One. 2014;9(5):e98507
1	J:28570 Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C, Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments]. Nature. 1995 Aug 31;376(6543):768-71
1*	J:17224 Bober E, Franz T, Arnold HH, Gruss P, Tremblay P, Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development. 1994 Mar;120(3):603-12
1*	J:55248 Borycki AG, Li J, Jin F, Emerson CP, Epstein JA, Pax3 functions in cell survival and in pax7 regulation. Development. 1999 Apr;126(8):1665-74
1	J:87223 Buttitta L, Mo R, Hui CC, Fan CM, Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development. 2003 Dec;130(25):6233-43
1*	J:142648 Castranio T, Mishina Y, Bmp2 is required for cephalic neural tube closure in the mouse. Dev Dyn. 2008 Dec 18;238(1):110-122
1*	J:223069 Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquie O, Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Sep;33(9):962-9
1*	J:141111 Chang CP, Stankunas K, Shang C, Kao SC, Twu KY, Cleary ML, Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development. 2008 Nov;135(21):3577-86
1*	J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
1	J:161813 Chilov D, Sinjushina N, Saarimaki-Vire J, Taketo MM, Partanen J, beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. PLoS One. 2010;5(6):e10881
1	J:236378 Choi HM, Calvert CR, Husain N, Huss D, Barsi JC, Deverman BE, Hunter RC, Kato M, Lee SM, Abelin AC, Rosenthal AZ, Akbari OS, Li Y, Hay BA, Sternberg PW, Patterson PH, Davidson EH, Mazmanian SK, Prober DA, van de Rijn M, Leadbetter JR, Newman DK, Readhead C, Bronner ME, Wold B, Lansford R, Sauka-Spengler T, Fraser SE, Pierce NA, Mapping a multiplexed zoo of mRNA expression. Development. 2016 Oct 1;143(19):3632-3637
1*	J:38385 Conway SJ, Henderson DJ, Copp AJ, Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development. 1997 Jan;124(2):505-14
1*	J:32016 Daston G, Lamar E, Olivier M, Goulding M, Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 1996 Mar;122(3):1017-27
1*	J:16484 Dietrich S, Schubert FR, Gruss P, Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev. 1993 Dec;44(2-3):189-207
1	J:65763 Eggenschwiler JT, Anderson KV, Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev Biol. 2000 Nov 15;227(2):648-60
1	J:61431 Epstein JA, Li J, Lang D, Chen F, Brown CB, Jin F, Lu MM, Thomas M, Liu E, Wessels A, Lo CW, Migration of cardiac neural crest cells in Splotch embryos. Development. 2000 May;127(9):1869-78
1	J:48859 Evrard YA, Lun Y, Aulehla A, Gan L, Johnson RL, lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 1998 Jul 23;394(6691):377-81
1*	J:76233 Faisst AM, Alvarez-Bolado G, Treichel D, Gruss P, Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos. Mech Dev. 2002 Apr;113(1):15-28
1	J:54101 Galceran J, Farinas I, Depew MJ, Clevers H, Grosschedl R, Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev. 1999 Mar 15;13(6):709-17
1	J:94049 Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R, LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 2004 Nov 15;18(22):2718-23
1	J:176262 Giros A, Grgur K, Gossler A, Costell M, alpha5beta1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One. 2011;6(7):e22002
1*	J:44237 Goh KL, Yang JT, Hynes RO, Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997 Nov;124(21):4309-19
1	J:177323 Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K, G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. J Exp Med. 2011 Apr 11;208(4):715-27
1*	J:65743 Harrison SM, Houzelstein D, Dunwoodie SL, Beddington RS, Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
1*	J:45678 Henderson DJ, Ybot-Gonzalez P, Copp AJ, Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch). Mech Dev. 1997 Dec;69(1-2):39-51
1*	J:54908 Houzelstein D, Auda-Boucher G, Cheraud Y, Rouaud T, Blanc I , Tajbakhsh S , Buckingham ME , Fontaine-Perus J , Robert B, The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb. Development. 1999 Jun;126(12):2689-701
1*	J:50279 Ikeya M, Takada S, Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome. Development. 1998 Dec;125(24):4969-76
1*	J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1	J:239189 Kraft-Sheleg O, Zaffryar-Eilot S, Genin O, Yaseen W, Soueid-Baumgarten S, Kessler O, Smolkin T, Akiri G, Neufeld G, Cinnamon Y, Hasson P, Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016 Mar 07;36(5):550-61
1*	J:73781 Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu LY, Liu YH, Ishii M, Sangiorgi FO, Rauchman M, Sucov HM, Maas RL, Maxson RE Jr, Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development. 2002 Jan;129(2):527-38
1*	J:137199 Lupu F, Alves A, Anderson K, Doye V, Lacy E, Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell. 2008 Jun;14(6):831-42
1	J:84754 Mankoo BS, Skuntz S, Harrigan I, Grigorieva E, Candia A, Wright CV, Arnheiter H, Pachnis V, The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development. 2003 Oct;130(19):4655-64
1	J:32018 Mansouri A, Stoykova A, Torres M, Gruss P, Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development. 1996 Mar;122(3):831-8
1	J:95326 McDermott A, Gustafsson M, Elsam T, Hui CC, Emerson CP Jr, Borycki AG, Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development. 2005 Jan;132(2):345-57
1	J:162916 Moore BA, Gonzalez Aviles GD, Larkins CE, Hillman MJ, Caspary T, Mitochondrial retention of Opa1 is required for mouse embryogenesis. Mamm Genome. 2010 Aug;21(7-8):350-60
1	J:346126 Pappas MP, Kawakami H, Corcoran D, Chen KQ, Scott EP, Wong J, Gearhart MD, Nishinakamura R, Nakagawa Y, Kawakami Y, Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)
1	J:41232 Phelan SA, Ito M, Loeken MR, Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. Diabetes. 1997 Jul;46(7):1189-97
1	J:177362 Rhinn M, Schuhbaur B, Niederreither K, Dolle P, Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16687-92
1	J:75491 Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ, Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
1	J:166040 Rocha PP, Scholze M, Bleiss W, Schrewe H, Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development. 2010 Aug;137(16):2723-31
1*	J:49903 Saga Y, Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement. Mech Dev. 1998 Jul;75(1-2):53-66
1*	J:316987 Sanchez-Ferras O, Coutaud B, Djavanbakht Samani T, Tremblay I, Souchkova O, Pilon N, Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer. J Biol Chem. 2012 May 11;287(20):16623-35
1	J:159213 Sato T, Rocancourt D, Marques L, Thorsteinsdottir S, Buckingham M, A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis. PLoS Genet. 2010;6(4):e1000897
1	J:106551 Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A, Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
1	J:135313 Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A, Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 2008 Feb;46(2):92-103
1	J:57891 Schafer K, Braun T, Early specification of limb muscle precursor cells by the homeobox gene Lbx1h. Nat Genet. 1999 Oct;23(2):213-6
1*	J:72525 Schubert FR, Tremblay P, Mansouri A, Faisst AM, Kammandel B, Lumsden A, Gruss P, Dietrich S, Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. Dev Dyn. 2001 Nov;222(3):506-21
1*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1*	J:53294 Solloway MJ, Robertson EJ, Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development. 1999 Apr;126(8):1753-68
1	J:155248 Song L, Li Y, Wang K, Zhou CJ, Cardiac neural crest and outflow tract defects in Lrp6 mutant mice. Dev Dyn. 2009 Aug 24;239(1):200-210
1*	J:77801 Soo K, O'Rourke MP, Khoo PL, Steiner KA, Wong N, Behringer RR, Tam PP, Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol. 2002 Jul 15;247(2):251-70
1*	J:30825 Sporle R, Gunther T, Struwe M, Schughart K, Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos. Development. 1996 Jan;122(1):79-86
1*	J:44060 Sporle R, Schughart K, System to identify individual somites and their derivatives in the developing mouse embryo. Dev Dyn. 1997 Nov;210(3):216-26
1	J:169133 Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM, Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development. 2011 Mar;138(5):1005-14
1	J:16716 Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA, McMahon AP, Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan;8(2):174-89
1	J:229586 Tondeleir D, Noelanders R, Bakkali K, Ampe C, Beta-actin is required for proper mouse neural crest ontogeny. PLoS One. 2014;9(1):e85608
1	J:161177 Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG, Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem. 2010 Apr 2;285(14):11023-30
1*	J:44659 Wilson-Rawls J, Hurt CR, Parsons SM, Rawls A, Differential regulation of epaxial and hypaxial muscle development by paraxis. Development. 1999 Dec;126(23):5217-29
1	J:108794 Wlodarczyk BJ, Tang LS, Triplett A, Aleman F, Finnell RH, Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients. Toxicol Appl Pharmacol. 2006 May 15;213(1):55-63
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:206311 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ, beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan;141(1):148-57
1	J:325944 Zhao T, McMahon M, Reynolds K, Saha SK, Stokes A, Zhou CJ, The role of Lrp6-mediated Wnt/beta-catenin signaling in the development and intervention of spinal neural tube defects in mice. Dis Model Mech. 2022 Jun 1;15(6):dmm049517